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Biographical Sketch

Cornelia van Duijn received a MSc degree from the Agricultural University Wageningen (1987) and a PhD degree from the Erasmus University (1992). Since 1992, she is head of the genetic-epidemiology section of the Department of Epidemiology . In 1997, Dr van Duijn received a Pioneer grant award of the Netherlands Organisation for Scientific research (NWO) for her work on the genetic-epidemiology of Alzheimer's disease. She is the program director of the NIHES international teaching programme in Genetic-Epidemiology (MSc, DSc, PhD). This is a collaborative programme with the Harvard University (Prof.dr D. Pauls) and Cambridge University (Prof.dr D Clayton). Prof. Van Duijn is part of the Center for Medical Systems Biology (CMSB) of the Genetics Focus Group in the Netherlands.

Selected Publications

Bonifati V, Rizzu P, Baren J van, Schaap O, Breedveld GJ, Krieger E, Dekker DCJ, Squitieri F, Ibanez P, Joosse M, Dongen JW van, Vanacore N, Swieten JC van, Brice A, Meco G, Duijn CM van, Oostra BA, Heutink P. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 2003;299:256-9.

Vaessen N, Janssen JA, Heutink P, Hofman A, Lamberts SW, Oostra BA, Pols HA, Duijn CM van. Assocation between genetic variation in the gene for insulin-like growth factor-I and low birth weight. Lancet 2002:359:1036-7.

Meijers-Heijboer H, Ouweland A van den, Klijn J, Wasielewski M, Snoo A de, Oldenburg R, Hollestelle A, Houben M, Crepin E, Veghel-Plandsoen M van, Elstrodt F, Duijn C van, et al. Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nat Genet 2002;31:55-9.

Croes EA, Roks G, Jansen GH, Nijssen PC, Duijn CM van. Creutzfeldt-Jakob disease 38 years after diagnostic use of human growth hormone. J Neurol Neurosurg Psychiatry 2002;72:792.

Kumar-Singh S, Cras P, Wang R, Kros JM, Swieten J van, Lubke U, Ceuterick C, Sernaals S, Vennekens K, Timmermans JP, Marck E van, Martin JJ, Duijn CM van. Broeckhoven C van. Dense-core senile plaques in the flemish variant of Alzheimer's disease are vasocentric. Am J Pathol 2002;161:507-20.

Njajou OT, Hollander M, Koudstaal PJ, Hofman A, Witteman JCM, Breteler MMB, Duijn CM van. Mutations in the hemochromatosis gene (HFE) and stroke. Stroke 2002;33:2363-6.

Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, Bougeueleret L, Barry C, Tanaka H, La Rosa P, Puech A, Tahri N, Cohen-Akenine A, Delabrosse S, Lissarrague S, Picard FP, Maurice K, Essioux L, Millasseau P, Grel P, Debailleul V, Simon AM, Caterina D, Dufaure I, Malekzadeh K, Belova M, Luan JJ, Bouillot M, Sambucy JL, Primas G, Saumier M, Boubkiri N, Martin-Saumier S, Nasroune M, Peixoto H, Delaye A, Pinchot V, Bastucci M, Guillou S, Chevillon M, Sainz-Fuertes R, Meguenni S, Aurich-Costa J, Cherif D, Gimalac A, Duijn C van, et al. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci U S A 2002;99:13675-80.

Maitland-van der Zee AH, Stricker BH, Klungel OH, Kastelein JJ, Hofman A, Leufkens HG, Broeckhoven C van, Duijn CM van, Boer A de. The effectiveness of HMG-CoA reductase inhibitors in an elderly population is independent of apolipoprotein E-genotypes. Br J Clin Pharmacol 2002;53:548P.

Slooter AJC, Bots ML, Havekes LM, Iglesias del Sol A, Cruts M, Grobbee DE, Hofman A, Broeckhoven C van, Witteman JCM, Duijn CM van. Apolipoprotein E and carotid artery atherosclerosis. The Rotterdam Study. Stroke 2001;32:1947-52.

Duijn CM van, Dekker MCJ, Bonifati V, Galjaard RJ, Houwing-Duistermaat JJ, Snijders PJLM, Testers L, Breedveld GJ, Horstink M, Sandkuijl LA, Swieten JC van, Oostra BA, Heutink P. PARK7, a novel locus for autosomal recessive early-onset parkinsonism on chromosome 1p36. Am J Human Genet 2001;69:629-34.

Veld BA in 't, Ruitenberg A, Hofman A, Launer LJ, Duijn CM van, Stijnen Th, Breteler MMB, Stricker BHCh. Nonsteroidal anti-inflammatory drugs and the risk of Alzheimer's disease. N Engl J Med 2001;345:1515-21.

Njajou OT, Vaessen N, Joosse M, Berghuis B, Dongen JWF van, Breuning MH, Snijders PJLM, Rutten WPF, Sandkuijl LA, Oostra BA, Duijn CM van, Heutink P. A mutation in SLC11A3 gene is associated with autosomal dominant hemochromatosis. Nature Genet 2001;28:214-5.

Rizzu P, Swieten JC van, Joosse M, Hasegawa M, Stevens M, Tibben A, Niermeijer MF, Hillebrand M, Ravid R, Oostra BA, Goedert M, Duijn CM van, Heutink P. High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands. Am J Hum Genet 1999;64:414-21.

Klaver CCW, Assink JJM, Bergen AAB, Duijn CM van. Re: ABCR gene and age-related macular degeneration. Science 1998;279:1107.

Duijn CM van, DelasnerieLaupretre N, Masullo C, Zerr I, de Silva R, Wientjens PWM, Brandel J-P, Weber T, Bonavita V, Zeidler M, Alperovitch A, Poser S, Granieri E, Hofman A, Will RG. For the EU Collaborative Study Group for CJD. Case-control study of risk factors of Creutzfeldt-Jakob disease in Europe during 199395. Lancet 1998;351:1081-5.

Ott A, Slooter AJC, Hofman A, Harskamp F van, Witteman JCM, Broeckhoven C van, Duijn CM van, Breteler MMB. Smoking and the risk of dementia and Alzheimer's disease in a population based cohort study: the Rotterdam study. Lancet 1998;351:1840-3.

Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak- Vance MA, Risch N, Duijn CM van; for APOE and Alzheimer Disease Meta-analysis Consortium. Effects of Age, gender and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. JAMA 1997;278:1349-56.

Hofman A, Ott A, Breteler MMB, Bots ML, Slooter AJC, Harskamp F van, Duijn CM van, Broeckhoven C van, Grobbee DE. Atherosclerosis, apolipoprotein E and the revalence of dementia and Alzheimer's disease in a population-based study: the Rotterdam Study. Lancet 1997;349:151-4.

Duijn CM van, Broeckhoven C van. Alzheimer's disease and the family effect. Nature Genet 1994;8:115.

Duijn CM van, Hendriks L, Farrer LA, Backhovens H, Cruts M, Wehnert A, Hofman A, Broeckhoven C van. A population-based study of familial Alzheimer's disease: linkage to chromosome 14, 19 and 21. Am J Hum Genet 1994;55:714-27.

Duijn CM van, Knijff P de, Cruts M, Wehnert A, Havekes LM, Hofman A, Broeckhoven C van. Apolipoprotein E E4 allele in a population-based study of early-onset Alzheimer's disease. Nature Genet 1994;7:74-8.

Hendriks L, Duijn CM van, Cras P, Cruts M, Hul W van, Harskamp F van, Warren A, McInnis MG, Antonarakis SE, Martin J-J, Hofman A, Broeckhoven C van. Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the b-amyloid precursor protein gene. Nature Genet 1992;1:218-21.

Research Interests

The focus of research of Dr van Duijn is on Alzheimer's disease and related disorders including Parkinson's disease, Creutzfeldt-Jakob disease, frontal lobe dementia and Down syndrome. Further, she studies the genetic-epidemiology of, osteoarthritis, diabetes, hypertension, and strokes. These studies involve genomic searches in family-based studies and in genetically isolated populations as well as candidate gene studies in the Rotterdam Study. With regard to population-based research, Dr van Duijn's prime interest is in gene-gene and gene-environment interaction. The development of approaches to study gene-interactions is one of the focuses in her methodologic work.