Henning Tiemeier, MD PhD
| || |
POSITION TITLE: Professor in Psychiatric Epidemiology
|Institution and location
||Field of Study
|University of Bonn, Medical School, Germany
|University of Bonn, Germany
|Erasmus University Medical Center, Rotterdam, The Netherlands
|Erasmus University Medical Center, Rotterdam, The Netherlands
I have been leading psychiatric epidemiology research in Rotterdam for the last fifteen years. This line evolved around two large population-based cohorts, the Rotterdam Study and Generation R. My research is mostly aimed at understanding risk factors for common psychiatric disorders and characterized by my interest in detailed phenotype assessment, neuroimaging, and genetics combined with modern quantitative methods. I have been planning, conducting and supervising all research conducted in the domains of cognitive, emotional and behavioral development in Generation R. I am responsible for the choice of the questionnaires, the hands-on assessments and experiments conducted with the parents and children. Our team obtained substantial funding which allowed us to perform home visits, detailed laboratory and brain imaging in large groups. My research focuses on genetic and early life exposures; as my previous work in Generation R showed that this shapes the vulnerability to neurodevelopmental problems. Recently, published studies focus on intra-uterine effects, and environmental and biological risk factors, but also highlight methodological problems involved in developmental studies. We have shown how neurodevelopmental processes and environmental risk factors underlie the vulnerability of children to develop internalizing and externalizing problems.
Much of my work is collaborative, I am (co) leader in several national and international consortia, including CHARGE-depression, CORNET, EAGLE-behaviour group and participates in the PGC consortium. I have published over 350 peer-reviewed publications and my current H-index is 45. I am regular keynote speaker at academic conferences both nationally and internationally
Positions and Honors
Positions and employment:
2013 - present: Adjunct Faculty Harvard School of Public Health, Boston, Professor of Epidemiology
2011 - present: Appointed Full Professor of Psychiatric Epidemiology at the Erasmus Medical Center
2003-2011 : Assistant and in 2008 Associate Professor in Psychiatric Epidemiology, Dep. of Epidemiology and Dep. of Child and Adolescent Psychiatry (50%), Sophia Children’s Hospital, Erasmus MC
1999-2002: Research fellow in Epidemiology, Dep. of Epidemiology & Biostatistics, Erasmus MC, Work: PhD thesis, Rotterdam Study Co-ordinator 2001-2002
1997-1999: Research fellow in Health Service Research, National Institute of Mental Health and Addiction (Trimbos-instituut), Utrecht. Work: Evidence-based treatment protocols for depression
1996-1997: Resident in Epileptology and Neurology, Dep. of Epileptology, University of Bonn, Germany. Work: Tertiary referral centre, patient care, EEG lab with intra- and scalp leads
Other Experience and Professional Memberships:
1991-1992: University of Manchester, United Kingdom, Medical studies, clinical year, EU Erasmus grant (DM 15.000)
2001 and 2002: INSERM Montpellier, Prof. Dr. K. Ritchie, Epidemiology, Inserm EMI 9930 "Pathologies du systčme nerveux : recherche épidémiologique et clinique" Montpellier, France. Two stays in Montpellier financed by a travel grant (€ 5400) provided by INSERM/NWO-ZonMw (910-48-604).
Jan - Aug 2005: Visiting Scholar, Child Psychiatry Branch, National Institute of Mental Health, Bethesda, NIMH (see scholarship)
Gezondheidsraad: Member of the committee of the Health Council of the Netherlands, No 718, Sleep, Health and Noise (2003-2004).
Faculty F1000 Medicine member: section Epidemiology. F1000 Medicine is run by leaders in medical research and clinical practice. These selected Faculty Members highlight and evaluate the most influential articles across medicine, sharing expert opinions and providing interpretation of current medical literature.
• Research Fellowship of the Sophia Stichting (2004-025/SWO) of € 22.689. Visiting scientist in the group of J. N. Giedd, Unit on Brain Imaging, Department of Child Psychiatry (head Prof. Dr. J.L. Rapoport) at the National Institute of Mental Health, Bethesda, Maryland, USA.
• Norbert and Charlotte Rieger Award of the American Academy of Child & Adolescent Psychiatry, 2008, for best scientific paper ($4500), together with Sabine Roza
• 2009 VIDI scheme (NWO-ZonMw 017.106.370). When sleep and depression come of age. The impact of altered circadian rhythms and disturbed sleep structure on late life depression. (€800.000)
• 2015 onwards: Adolescent Brain Cognitive Development (ABCD) Study. Only international External Advisory Board Member invited and appointed by Nora Volkow, head NIDA, NIH.
Contributions to Science
1. I have been investigating common psychiatric problems in children and elderly. One focus has been on risk mechanisms and consequences of depressive disorders; in addition anxiety disorders, sleep disturbances and complicated grief are being studied. In ongoing projects, diurnal patterns of cortisol secretion, sleep fragmentation, genetic variations and brain morphology are studied. Current data collection also includes a dexamethasone suppression test to measure hypothalamic-pituitary-adrenal axis activity in all participants, which is unique in a large population-based study.
a) Gottlieb DJ, Hek K, Chen TH, Watson NF, Eiriksdottir G, Byrne EM, Cornelis M, Warby SC, Bandinelli S, Cherkas L, Evans DS, Grabe HJ, Lahti J, Li M, Lehtimaki T, (…) Gudnason V, Hu F, Mangino M, Martin NG, O'Connor GT, Stone KL, Tanaka T, Viikari J, Gharib SA, Punjabi NM, Raikkonen K, Volzke H, Mignot E, Tiemeier H. Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study. Mol Psychiatry 2015;20(10):1232-9.
b) Hek K, Demirkan A, Lahti J, Terracciano A, Teumer A, Cornelis MC, (…) Tiemeier H. A genome-wide association study of depressive symptoms. Biol Psychiatry. 2013 Apr 1;73(7):667-78.
c) Mirza SS, de Bruijn RFAG, Direk N, Hofman A, Koudstaal PJ, Ikram MA, Tiemeier H. Depressive Symptoms Predict Incident Dementia During Short- but Not Long-Term Follow-up Period. Alzheimer's and Dementia. 2014 ;10(5 Suppl):S323-S329.
d) Saavedra Pérez HC, Ikram MA, Direk N, Prigerson HG, Freak-Poli R, Verhaaren BF, Hofman A, Vernooij M, Tiemeier H. Cognition, structural brain changes and complicated grief. A population-based study. Psychol Med. 2015 May;45(7):1389-99.4.
e) Newson RS, Hek K, Luijendijk HJ, Hofman A, Witteman JC, Tiemeier H. Atherosclerosis and incident depression in late life. Arch Gen Psychiatry. 2010;67:1144-51.
2. Since 2002, I supervise the child psychiatric and cognitive research the Generation R birth cohort of nearly 8000 children and their mothers in Rotterdam. Together with several external partners, I introduced innovative child assessments unique to large-scale behaviour studies including postnatal ultrasound, Strange Situation Procedure, neuromotor assessment, home environment and executive function measures. Large observational cohorts of more than 1000 persons often rely on questionnaire data only, rather than assessing behaviour, parent-child interaction and parenting in the laboratory. This line of research has been very well received as reflected in several high impact publications (for the developmental field), many collaboration requests, received grants and invited talks.
a) Kok R, Thijssen S, Bakermans-Kranenburg MJ, Jaddoe VW, Verhulst FC, White T, van IJzendoorn MH, Tiemeier H. Normal Variation in Early Parental Sensitivity Predicts Child Structural Brain Development. J Am Acad Child Adolesc Psychiatry. 2015 Oct;54(10):824-831.
b) Verlinden M, Jansen PW, Veenstra R, Jaddoe VW, Hofman A, Verhulst FC, Shaw P, Tiemeier H. Preschool Attention-Deficit/Hyperactivity and Oppositional Defiant Problems as Antecedents of School Bullying. J Am Acad Child Adolesc Psychiatry. 2015; 54:571-9.
c) Dierckx B, Kok R, Tulen JH, Jaddoe VW, Hofman A, Verhulst FC, Bakermans-Kranenburg MJ, van Ijzendoorn MH, Tiemeier H. A Prospective Study of Heart Rate and Externalising Behaviours in Young Children. Journal of Child Psychology and Psychiatry. 2013.
d) Cents RAM, Kok R, Tiemeier H, Lucassen N, Székely E, Bakermans-Kranenburg MJ, Hofman A, Jaddoe VW, van Ijzendoorn MH, Verhulst FC, Lambregtse -van den Berg MP. Variations in Maternal 5-Httlpr Affect Observed Sensitive Parenting. Journal of Child Psychology and Psychiatry. 2014
e) Szekely E, Lucassen N, Tiemeier H, Bakermans-Kranenburg MJ, Van Ijzendoorn MH, Kok R, Jaddoe VW, Hofman A, Verhulst FC, Herba CM. Maternal Depressive Symptoms and Sensitivity Are Related to Young Children's Facial Expression Recognition: The Generation R Study. Dev Psychopathol. 2014:1-13.
3. From the work conducted in Generation R by my group, perhaps the most notable is our prize-winning work on pre- and postnatal ultrasound that demonstrated the neurodevelopmental origin of common behavioural problems and very recent work showing the effects of prenatal exposure of the mother to SSRIs on offspring head growth. Core to many current research activities is population-based structural brain imaging, to date more than 4000 MRI (700 repeated) have been collected in children and pre-adolescents participating in the cohort. Together with my colleagues, co-workers and collaborators these assessments form the basis of Population Neuroscience, which I see as neurodevelopmental epidemiology integrating molecular genetics, epigenetics, behaviour and imaging to overcome the limitations and bias inherent to many cross-sectional convenience samples traditionally studied in the field.
a) Ghassabian A, Herba CM, Roza SJ, Govaert P, Schenk JJ, Jaddoe VW, Hofman A, White T, Verhulst FC, Tiemeier H. Infant Brain Structures, Executive Function, and Attention Deficit/Hyperactivity Problems at Preschool Age. A Prospective Study. Journal of Child Psychology and Psychiatry. 2013;54(1):96-104.
b) van der Knaap NJ, El Marroun H, Klumpers F, Mous SE, Jaddoe VW, Hofman A, Homberg JR, White T, Tiemeier H, Fernández G. Beyond classical inheritance: the influence of maternal genotype upon child's brain morphology and behavior. J Neurosci. 2014;34(29):9516-21.
c) El Marroun H, Schmidt MN, Franken IH, Jaddoe VW, Hofman A, van der Lugt A, Verhulst FC, Tiemeier H, White T. Prenatal tobacco exposure and brain morphology: a prospective study in young children. Neuropsychopharmacology. 2014;39(4):792-800.
d) Blanken LM, Mous SE, Ghassabian A, Muetzel RL, Schoemaker NK, El Marroun H, van der Lugt A, Jaddoe VW, Hofman A, Verhulst FC, Tiemeier H, White T. Cortical Morphology in 6- to 10-Year Old Children With Autistic Traits: A Population-Based Neuroimaging Study. Am J Psychiatry. 2015 172(5):479-86; PMID: 25585034.
4. We began a research line of eating problems and obesity several years ago. We repeatedly assessed infant and toddler eating and feeding behavior, Dr. Micali suggested an in depth assessment at age 4 years and advised on measures to be used at the 10 years of age wave. In the last years we conducted a series of projects to study environmental, family and genetic determinants of eating behavior and obesity. A co-worker in my team received a prestigious grant to study eating behavior, parenting and child obesity/metabolism. The present proposal will thus combine several strengths of the team and the Generation R data collection.
a) Cardona Cano S, Hoek HW, Hoeken D, Barse LM, Jaddoe VW, Verhulst FC, Tiemeier H. Behavioral outcomes of picky eating in childhood: a prospective study in the general population. Journal of Child Psychology and Psychiatry. 2016 Feb 1 (Epub).
b) Jansen PW, Verlinden M, Dommisse-van Berkel A, Mieloo CL, Raat H, Hofman A, Jaddoe VW, Verhulst FC, Jansen W, Tiemeier H. Teacher and peer reports of overweight and bullying among young primary school children. Pediatrics. 2014;134(3):473-80.
c) Tharner A, Jansen PW, Kiefte-de Jong JC, Moll HA, Hofman A, Jaddoe VW, Tiemeier H, Franco OH. Bidirectional associations between fussy eating and functional constipation in preschool children. J Pediatr. 2015;166:91-6.
d) Jansen PW, Tharner A, van der Ende J, Wake M, Raat H, Hofman A, Verhulst FC, van Ijzendoorn MH, Jaddoe VW, Tiemeier H. Feeding practices and child weight: is the association bidirectional in preschool children? Am J Clin Nutr. 2014;100(5):1329-36.
2016-2017: Hersenstichting Nederland, Dutch Brain Foundation
GH2015.4.01, How do the Dutch sleep? A meta-analysis of sleep duration and sleep patterns in the Netherlands
2015-2020: EU Horizon 2020 PHC-03-2015 CoSTREAM: Common mechanisms
The primary goal is to study common mechanisms and pathways in Stroke and Alzheimer's disease; http://cordis.europa.eu/project/rcn/199731_en.html
Role: PI: Tiemeier (jointly with A. Ikram and C. van Duijn)
2009-2015: Sophia Children’s Hospital Research Foundation (PI: Tiemeier H):
The development of ADHD. An epigenetic neuronal gene network approach
The primary aim of this grant is to examine the relation between epigenetic changes occurring during the fetal period and the development of ADHD.
2009-2015: EU FP 7 (PI: Boomsma)
Health Innovation 1 Action: Aggression in Children: Unravelling gene and environment interplay to inform treatment strategies
The primary goal is to investigate interplay between genetic, biological, and environmental pathways leading to aggression. Ultimately, this research will provide insight into novel interventions, taking into account individual differences in genetic and environmental susceptibility.
2014-2018: Erasmus MC MRACE-programme (PI: Tiemeier H)
No rest for the wicked. Family chaos disturbs circadian rhythm in children problem behaviour
The primary aim of this grant is to investigate whether the association between family chaos and externalizing problems in children is mediated by candidate gene (clock gene) epigenetic changes.
2014-2019: Netherlands Organization f. Scientific Research (NWO-Gravity) (PI: Kemner )
Individual development: Why some children thrive, and others don’t
This project aims to understand the role of brain development and interplay between environment and child psychological characteristics on developmental differences.
2012-2016: Sophia Children’s Hospital Research Foundation (PI: Tiemeier H) br>
Intergenerational transmission of Oppositional Defiant Disorder (ODD): an epigenetic process?
The aim of this longitudinal study is to better understand how environmental factors mark the epigenome and how these epigenetic profiles are associated with ODD in children.