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Biographical Sketch

Jacqueline C.M. Witteman received an MSc degree from Wageningen University (1985) and a PhD degree in epidemiology from Erasmus University Rotterdam (1991). Her training included a one-year fellowship at the Harvard School of Public Health, Boston. Since 1996, she is head of the Cardiovascular Epidemiology group of the department of Epidemiology Biostatististics of Erasmus Medical Center, Rotterdam. In 2006, she received a grant award from the Netherlands Organisation for Scientific Research (Vici) for her work on subclinical measures of cardiovascular disease.

Selected Publications

1. Van der Meer IM, Bots ML, Hofman A, del Sol AI, Van der Kuip DA, Witteman JC. Predictive value of non-invasive measures of atherosclerosis for incident myocardial infarction: the Rotterdam Study. Circulation 2004;109:1089-94.

2. Oei HH, Van der Meer IM, Hofman A, Koudstaal PJ, Stijnen T, Breteler MM, Witteman JC. Lipoprotein-associated phospholipase A2 activity is associated with risk of coronary heart disease and ischemic stroke: the Rotterdam Study. Circulation 2005;111:570-5.

3. Vliegenthart R, Oudkerk M, Hofman A, Oei HHS, Van Dijck W, Van Rooij F, Witteman JCM. Coronary calcification improves cardiovascular risk prediction in a population of older adults. Circulation 2005;112:572-7.

4. Mattace-Raso FUS, Van der Cammen TJM, Hofman A, Van Popele NM, Bos ML, Schalekamp MADH, Asmar R, Reneman RS, Hoeks A, Breteler MMB, Witteman JCM. Arterial stiffness and risk of coronary heart disease and stroke. The Rotterdam Study. Circulation 2006;113:657-63.

5. Kardys I, Klaver CC, Despriet DD, Bergen AA, Uitterlinden AG, Hofman A, Oostra BA, Van Duijn CM, De Jong PT, Witteman JC. A common polymorphism in the complement factor H gene is associated with increased risk of myocardial infarction. The Rotterdam Study. J Am Coll Cardiol 2006;47:1568-75.

Research Interests

Dr. Witteman’s research focuses on risk factors for atherosclerosis and coronary heart disease. Among the determinants investigated in recent work are endocrine factors and factors involved in hemostasis, inflammation and endothelial function. The studies include novel, non-invasive imaging techniques for the assessment of vascular changes, among which fast CT and high-resolution MRI techniques. In addition, she studies genetic determinants of several clinical and endophenotypes. Most studies are conducted in the prospective, population-based Rotterdam Study in close collaboration with the departments of Internal Medicine, Cardiology and Radiology of Erasmus Medical Center.